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EC number: 203-570-0
CAS number: 108-30-5
Table 1. Body mass index of animals
on days 1 and 6
Table 2. General observations and
observations of the application sites on days 1 -6
In a dermal sensitization study conducted
according to OECD TG 429 with succinic anhydride (99.5%) in
dimethlformamide, three groups of 4 female young adult CBA/CaOlaHsd
mice/dose group were tested in the local lymph node assay.
Succinic anhydride was administered
epicutaneously to the dorsal surface of both ears, once a day on three
consecutive days, at concentrations of 10%, 25%, or 31.3% (w/w). The
volume administered was 25 uL per ear. Positive (25% hexyl cinnamic
aldehyde in acetone:olive oil) and negative control (dimethylformamide)
groups were tested concurrently under identical conditions. Five days
after topical administration, 3H-methyl thymidine was administered
intravenously to all mice via a tail vein. Approximately 5 hours later,
the draining auricular lymph nodes were excised, incorporation of
radiolabelled 3HTdR was determined and compared with negative controls,
and the SI index was calculated.
No adverse effects were noted in any animal.
The SIs of the test substance concentrations were 9.2 (low dose), 11.6
(mid dose), and 11.0 (high dose). Although no clear dose response was
observed, the SIs of all test substance concentrations were greater than
3 and succinic anhydride is regarded as a sensitizer in the LLNA.
Based on these results, classification of
succinic anhydride as skin sensitizer Category 1 according to the CLP
criteria set out in Regulation (EC) 1272/2008 is warranted.
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