Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-570-0
CAS number: 108-30-5
The percutaneous absorption of
hexahydrophthalic anhydride was very low following application to the
skin of three human volunteers. Cyclic anhydrides, such as
hexahydrophthalic acid, are readily hydrolyzed to the corresponding
dicarboxylic acids and the excreted amounts of hexahydrophthalic acid in
the three volunteers were between 0% and 4.5% of the total applied dose.
The subject with the highest excretion showed mild skin effects which
suggested that inflamed skin may permit higher dermal absorption.
Cyclic anhydrides share structural and
physicochemical properties such that toxicokinetic data on
hexahydrophthalic anhydride can be used to read-across to succinic
anhydride. The hydrolysis product of succinic anhydride is succinic
acid, an endogenous substance and food ingredient, that is expected to
show minimal absorption by the dermal route. A separate percutaneous
absorption study on succinic anhydride is not proposed and cannot be
justified based upon animal welfare considerations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Ce site web utilise des cookies afin de vous garantir la meilleure expérience possible sur nos sites web.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again