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EC number: 203-570-0
CAS number: 108-30-5
In a primary eye irritation/corrosion study
performed according to OECD TG 405, 100 mg of succinic acid (purity:
min. 99.5%) was instilled into the conjunctival sac of the right eye of
one female New Zealand White rabbit for 24 hours. After the instillation
of the test substance, the conjunctival sacs of both eyes were rinsed
with warm tap water to remove residual test substance. Anmals were then
observed for 21 days. Irritation was scored by the method of Draize.
Severe and irreversible corneal alterations
were observed until day 21. The iris was not discernible because of
severe corneal opacity. Pronounced conjunctival redness was observed
which gradually decreased in severity but did not fully resolve. Severe
conjunctival swelling was noted which was reversible until day 15. In
addition, a dermal swelling dorsal of the test eye was noted.
In this study, succinic acid caused severe
damage to the eye, based on irreversible ocular lesions that failed to
fully resolve within 21 days after instillation.
Based on these results, classification of
succinic anhydride as Cat. 1 (serious damage to eyes) is warranted
according to CLP criteria as set out in Regulation 1272/2008.
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