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EC number: 203-570-0
CAS number: 108-30-5
Table 1: Mean absorption in the in
vitro skin corrosion test with Succinic anhydride
Table 2: Mean tissue viability in
the in vitro skin corrosion test with Succinic anhydride
In a primary skin corrosion study
conducted according to OECD testing guideline 431, two EpiDerm tissues
per dose group were exposed to 25 mg of Succinic anhydride (99.7%
purity) for 60 min and 3 min. Cytotoxicity was measured in comparison to
the concurrent negative controls via the MTT reduction assay and
irritation was scored by the method of mean relative tissue viability.
The test item showed corrosive effects. The mean relative tissue
viability (% negative control) was below 15% (12%) after 60 min
treatment and greater than 50% (96%) after a 3 min treatment. The
controls confirmed the validity of the study and all acceptance criteria
were fulfilled. Based on the results from this study, the test item can
be classified as corrosive.
The study is acceptable and satisfies
the guideline requirements for an in vitro skin corrosion study (OECD
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