Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-570-0
CAS number: 108-30-5
Table 1: Mean absorption in the in
vitro skin corrosion test with Succinic anhydride
Table 2: Mean tissue viability in
the in vitro skin corrosion test with Succinic anhydride
In a primary skin corrosion study
conducted according to OECD testing guideline 431, two EpiDerm tissues
per dose group were exposed to 25 mg of Succinic anhydride (99.7%
purity) for 60 min and 3 min. Cytotoxicity was measured in comparison to
the concurrent negative controls via the MTT reduction assay and
irritation was scored by the method of mean relative tissue viability.
The test item showed corrosive effects. The mean relative tissue
viability (% negative control) was below 15% (12%) after 60 min
treatment and greater than 50% (96%) after a 3 min treatment. The
controls confirmed the validity of the study and all acceptance criteria
were fulfilled. Based on the results from this study, the test item can
be classified as corrosive.
The study is acceptable and satisfies
the guideline requirements for an in vitro skin corrosion study (OECD
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Ce site web utilise des cookies afin de vous garantir la meilleure expérience possible sur nos sites web.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again