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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2008-11-20 to 2009-12-16
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
no
Remarks:
ISO 9001 quality management system adopted
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
2.44
Temp.:
40 °C
pH:
5.8
Details on results:
The repeatability was within a range of less than +/- 0.1 log10 units. The correlation coefficient R was 0.9749 (>0.9).

Table 1. Repeatability of Log Pow measurements of succinic anhydride

 Injection Number  Log Pow
 1  2.44
 2 2.44 
2.44 
 4 2.44 
 Mean  2.44
 Fall range  0.00

Table 2. Calibration data

 Injection  Average Retention Time  Average Log k  Referenced Log Pow
 Thiourea (dead time)  1.591    
 Acetanilide  1.905 -0.705 
 2 -Nitrophenol  2.399 -0.294  1.8 
 Toluene  3.559 0.092  2.7 
 Naphthalene  4.013 0.182  3.6
 Phenanthrene  5.866  0.429  4.5
 DDT  12.333 0.829  6.5 

Table 3. Retention data for succinic anhydride

 Injection Number  Retention time  Log k'
 1  2.680  -0.165
 2  2.679 -0.165 
 3 2.679  -0.165 
2.681  -0.164 
 Mean  2.680  -0.165
Conclusions:
The partition coefficient of succinic anhydride was experimentally measured and determined to be 2.44.
Executive summary:

In a non-GLP study according to OECD 117 the partition coefficient of succinic anhydride has been determined using the HPLC method. All relevant validity criteria were fulfilled. The analytical method for determination of succinic anhydride was validated and tested with satisfactory results in regards to elution time. The partition coefficient (n-octanol/water) of succinic anhydride was determined to be Log10 Pow = 2.44.

Description of key information

In a non-GLP study according to OECD 117 the partition coefficient of succinic anhydride has been determined using the HPLC method. All relevant validity criteria were fulfilled. The analytical method for determination of succinic anhydride was validated and tested with satisfactory results in regards to elution time. The partition coefficient (n-octanol/water) of succinic anhydride was determined to be Log10Pow= 2.44.

Key value for chemical safety assessment

Log Kow (Log Pow):
2.44
at the temperature of:
40 °C

Additional information