Succinic anhydride

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2008-11-20 to 2009-12-16

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Deviations:

no

GLP compliance:

no

Remarks:

ISO 9001 quality management system adopted

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

2.44

Temp.:

40 °C

pH:

5.8

Details on results:

The repeatability was within a range of less than +/- 0.1 log10 units. The correlation coefficient R was 0.9749 (>0.9).

Table 1. Repeatability of Log Pow measurements of succinic anhydride

Injection Number	Log Pow
1	2.44
2	2.44
3	2.44
4	2.44
Mean	2.44
Fall range	0.00

Table 2. Calibration data

Injection	Average Retention Time	Average Log k	Referenced Log Pow
Thiourea (dead time)	1.591
Acetanilide	1.905	-0.705	1
2 -Nitrophenol	2.399	-0.294	1.8
Toluene	3.559	0.092	2.7
Naphthalene	4.013	0.182	3.6
Phenanthrene	5.866	0.429	4.5
DDT	12.333	0.829	6.5

Table 3. Retention data for succinic anhydride

Injection Number	Retention time	Log k'
1	2.680	-0.165
2	2.679	-0.165
3	2.679	-0.165
4	2.681	-0.164
Mean	2.680	-0.165

Conclusions:

The partition coefficient of succinic anhydride was experimentally measured and determined to be 2.44.

Executive summary:

In a non-GLP study according to OECD 117 the partition coefficient of succinic anhydride has been determined using the HPLC method. All relevant validity criteria were fulfilled. The analytical method for determination of succinic anhydride was validated and tested with satisfactory results in regards to elution time. The partition coefficient (n-octanol/water) of succinic anhydride was determined to be Log₁₀ P_ow = 2.44.

Description of key information

In a non-GLP study according to OECD 117 the partition coefficient of succinic anhydride has been determined using the HPLC method. All relevant validity criteria were fulfilled. The analytical method for determination of succinic anhydride was validated and tested with satisfactory results in regards to elution time. The partition coefficient (n-octanol/water) of succinic anhydride was determined to be Log₁₀P_ow= 2.44.

Key value for chemical safety assessment

Log Kow (Log Pow):

2.44

at the temperature of:

40 °C