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EC number: 203-570-0
CAS number: 108-30-5
Nominal concentration (mg/L)
Measured concentration (mg/L)
The limit of quantification was 3.55 mg/L. All
of the control measurements were less than the LOQ.
In a 96-h acute toxicity study, juvenile zebrafish (Danio rerio) were exposed to a single succinic acid concentration of 100 mg/L under semi-static conditions (48-h and 72-h media change). The 96-h LC50 was > 100 mg /L. The NOEC value, based on mortality, was 100 mg/L. No sublethal effects were observed. The test design included an untreated control comprising of dilution water only. The concentration of succinic acid was verified analytically, and the mean measured concentration was 95.07 mg/L. Since this was within 80 % of the initial concentration, nominal exposure concentrations were used throughout the duration of the test.
This toxicity study is classified as acceptable and satisfies the guideline requirements for OECD 203 acute fish toxicity studies. Based on the results of this study, succinic acid does not need to be classified in regards to environmental hazards according to Regulation (EC) No 1272/2008 (Part 4) and Directive 67/548/EEC
Test organism size/age: 40 weeks, 3.21 cm (SD: 0.21)
Test type: Semi-Static (media change 48 and 72hr)
LC50: > 100 mg/L
Endpoint(s) effected: Mortality
This information is used in a read-across approach in the assessment of the target substance. For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
The potential toxicity of succinic anhydride to aquatic invertebrates is assessed via read-across from its hydrolytical transformation product succinic acid.
In the key study on the acute toxicity of the hydrolysis product (succinic acid) of succinic anhydride to fish according to OECD 203 (Ipser, 2010), juvenile zebrafish (Danio rerio) were exposed to a single succinic acid concentration of 100 mg/L under semi-static conditions (48-h and 72-h media change). The 96-h LC50 was > 100 mg /L and the NOEC value, based on mortality, was 100 mg/L, both corresponding to 85 mg/L succinic anhydride. No sublethal effects were observed.
Based on the results of this study, succinic anhydride does not need to be classified in regard to environmental hazards according to Regulation (EC) No 1272/2008 (Part 4) and Directive 67/548/EEC.
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