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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2003
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
publication
Title:
OECD SIDS 1,2-DICHLOROPROPANE
Author:
OECD SIDS
Year:
2003
Bibliographic source:
UNEP PUBLICATIONS
Report date:
2003

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EPA OPPTS 870.5395 (In Vivo Mammalian Cytogenetics Tests: Erythrocyte Micronucleus Assay)
GLP compliance:
yes
Type of assay:
micronucleus assay

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-dichloropropane
EC Number:
201-152-2
EC Name:
1,2-dichloropropane
Cas Number:
78-87-5
Molecular formula:
C3H6Cl2
IUPAC Name:
1,2-dichloropropane
Details on test material:
Name. 1,2-dichloropropane

Test animals

Species:
mouse
Strain:
CD-1
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Duration of treatment / exposure:
48 hr
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 150, 300 or 600 mg/kg bwt/d
Basis:

Results and discussion

Any other information on results incl. tables

All animals survived until the end of the observation period. Incoordination was observed in one mouse from the high-dose group. A uniform drop in body temperature (approx. 2ºC) occurred 2 hrs post-dosing in the high-dose animals. There was no statistically significant increase in the frequencies of MN-PCE in groups treated with PDC when compared to the negative controls. In contrast, a significant increase in the frequency of MN-PCE was recorded in the positive control group. The mean proportion of PCE among bone marrow erythrocytes (200/animal) was unaffected by exposure to the test material while the positive control treatment significantly reduced this value.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative
1,2 dichloropropane was negative for the induction of micronuclei in this test system under the experimental conditions used.