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EC number: 201-152-2
CAS number: 78-87-5
excellent package of GLP experimental studies have been performed to
cover the mutagenicity potential in bacteria and mammalian cells “in
vitro” as well as “in vivo” approach. All studies were performed both
with metabolic activation and without metabolic activation in order to
check if any metabolic process can activate or enhance the mutagenic
effects, if any.
from in vitro genotoxicity tests (bacterial, fungal, mammalian systems;
with and without
Endpoint Conclusion: No adverse effect observed (negative)
Based on the results of the reported studies
and taking into account the literature, 1,2-dichloropropane does not
meet the classification criteria as genotoxic.
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