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EC number: 201-152-2
CAS number: 78-87-5
PDC did not demonstrate any lymph node cell proliferation response, nor
any LLNA results (dpm and SI) consistent with dermal sensitization as
the lymph nodes draining the area of topical application did not
demonstrate a proliferative response equal to or greater than the 3x
threshold. SI values were consistently around 1.0 (equivalent to vehicle
controls) at all doses tested:
1.0 +/- 0.7
1.0 +/- 0.6
1.3 +/- 0.9
0.8 +/- 0.5
Proper conduct and responsiveness of the test was confirmed in animals
treated with 30% HCA (positive control group) where proliferation (SI)
was 14-fold greater than that of vehicle controls. Because the SI values
for 5, 20, and 80% PDC were all below 3, an EC3 value could not be
determined. On the basis of these results, PDC did not demonstrate any
contact sensitization potential.
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