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EC number: 201-152-2
CAS number: 78-87-5
IR analysis demonstrated that the mean concentration of PDC within the
chamber (SD in brackets) was 0, 15(1), 50(3) or 151(3) ppm.
Clinical observations and body weight
No clinical signs or evidence of overt toxicity were recorded in any of
the treated animals, while body weights were indistinguishable from
those of the controls.
RBC and HGB were slightly but significantly decreased (approx. 5%) in
low and high dose male mice (no effect at 50 ppm, all treated females
indistinguishable from controls). PCV was statistically significantly
increased in low dose animals (no effect in mid and high dose groups).
The authors concluded these findings were of doubtful toxicological
relevance given the lack of a clear dose-response relationship and an
absence of histopathological involvement in bone marrow or spleen. All
other heamatological parameters were comparable between the control and
Body weight and organ weights (relative and absolute) were unaffected by
No treatment related histopathological changes were present.
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