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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
long-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2003
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
publication
Title:
OECD SIDS 1,2-DICHLOROPROPANE
Author:
OECD SIDS
Year:
2003
Bibliographic source:
UNEP PUBLICATIONS
Report date:
2003

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
for method see "Materials and methods"
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-dichloropropane
EC Number:
201-152-2
EC Name:
1,2-dichloropropane
Cas Number:
78-87-5
Molecular formula:
C3H6Cl2
IUPAC Name:
1,2-dichloropropane
Details on test material:
Name: 1,2-dichloropropane

Sampling and analysis

Analytical monitoring:
yes

Test organisms

Test organisms (species):
Pimephales promelas

Study design

Total exposure duration:
28 d

Results and discussion

Effect concentrations
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
6 - 11 mg/L

Any other information on results incl. tables

Measured exposure concentrations were 0, 6, 11, 25, 51 and 110 mg/l. Embryo hatchability was 96% - 98%, with no treatment-related differences apparent, however the percentage of normal larvae was decreased significantly in the 51 mg/l and 110 mg/l tanks (decreased 33% and 100%, respectively). Body weight at day 28 was reduced significantly in larvae exposed to 11 mg/l and above, while larval survival was significantly decreased at 25 mg/l and above. The authors estimate that the Maximum Acceptable Toxicant Concentration (MATC, defined as a hypothetical toxic threshold falling mid-way between the NOEC and LOEC) for PDC is 59 mg/l.

Applicant's summary and conclusion

Conclusions:
Under the conditions of this ELS test in Fathead minnows, a chronic NOEC of 6 mg/l was obtained for growth and a chronic NOEC of 11 mg/l obtained for survival.