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EC number: 201-152-2
CAS number: 78-87-5
The measured concentration of PDC in the chambers was 4.6/4.7 ppm,
52.4/56.8 ppm and 141.8/125.2 ppm for males/females, respectively, in
the low, mid and high exposure groups, respectively. Mean end exposure
body burdens were 0.4/0.3, 2.8/2.8 and 6.3/7.1 mg equivalents of PDC for
males/females in the low, mid and high exposure groups, respectively.
The distribution of recovered radioactivity is summarized in Attachment
5.0b. In summary, urine (54-66% of recovered dose) and expired air
(15-23% as carbon dioxide) were the principle routes of excretion with
smaller amounts present in tissues and carcass (6-10%) and faeces
(6-10%). Less than 4% of the recovered radioactivity was present in cage
washings. Exhaled volatiles accounted for 2-3% of the dose in animals
exposed to 5 ppm and 50 ppm, and 6-7% in the 100 ppm group (high dose
group significantly different from mid and low dose groups). The pattern
of excretion did not differ between males and females.
Analysis of tissues
Radioactivity was distributed among all the tissues examined and
generally represented less than 0.18% of the recovered dose/g wet
weight. The liver and kidneys contained the highest amount of
radioactivity, accounting for 0.1-0.3% and 0.1-0.2% of the dose/g wet
weight, respectively. There were no obvious differences in tissue
distribution between the sexes or in distribution or concentration for
the different exposure concentrations.
Timecourse for elimination
elimination of radiolabel was greatest over the first 24 hr post-dosing
(47-62% of dose) relative to the following 24 hr (2-9%). Comparative
figures for exhaled carbon dioxide were 13-20% and <3%, and 5-8% and
0.7-3.0% for faeces (at 0-24 and 24-48 hr, respectively). The majority
of exhaled volatiles were also eliminated during the 24 hr following
exposure, with <0.03% detected during the 24-48 hr time period.
Blood concentrations in both sexes were generally at a maximum 4 hr into
the exposure (exception: 5 ppm females which peaked at 1 hr). In both
sexes the peak blood PDC level was not proportional to dose indicating a
dose-dependent non-linearlity in clearance. The concentration in blood
was below the limit of detection (0.03 ug/g) 2 hr after exposure ended.
Modelling (one-compartment open model with linear fit) indicated a
post-exposure blood clearance half life for PDC of 30 min in males and
24 min in females.
In plasma, the highest concentration of 14C in both sexes was found at 4
hr in the exposure, and ranged from 2, 12-15 and 27-29 ug eq/g plasma
present in the 5, 50 and 100 ppm groups respectively. Corresponding AUCs
were 21-23, 130-134 and 288-320 ug g^-1, respectively. Comparison of the
5 ppm peak plasma 14C level and AUC with the mid- and high dose groups
indicated that plasma 14C was less than proportional to dose.
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