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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2003
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2003
Report date:
2003

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: standard NTP methodology
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-dichloropropane
EC Number:
201-152-2
EC Name:
1,2-dichloropropane
Cas Number:
78-87-5
Molecular formula:
C3H6Cl2
IUPAC Name:
1,2-dichloropropane
Details on test material:
Name. 1,2-dichloropropane

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Duration of treatment / exposure:
14 days
Frequency of treatment:
Consecutive days
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 125, 250, 500, 1000 or 2000 mg/kg bw/d
Basis:

No. of animals per sex per dose:
Groups of 5 male and 5 female
Control animals:
yes, concurrent vehicle

Results and discussion

Effect levels

open allclose all
Key result
Dose descriptor:
NOAEL
Effect level:
500 mg/kg bw/day (nominal)
Sex:
male/female
Basis for effect level:
mortality
Key result
Dose descriptor:
LOAEL
Effect level:
1 000 mg/kg bw/day (nominal)
Sex:
male/female
Basis for effect level:
mortality

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

GC analysis of the dosing solutions demonstrated that the achieved concentration was 95 - 100% of target. All rats given 2000 mg/kg bw died during the study, along with a single male from the 125 mg/kg bw/d group. Final mean body weight was decreased 14-15% in animals given 1000 mg/kg bw/d relative to the controls. The renal medullae were red in 4/5 males and 5/5 females given 2000 mg/kg bw/d but not in rats from the lower treatment groups.

Applicant's summary and conclusion

Conclusions:
Under the conditions of the study, the sub-acute NOEL for PDC in male and female rats was 500 mg/kg bw/d.