Registration Dossier

Diss Factsheets

Toxicological information


Currently viewing:

Administrative data

Description of key information

Two chronic dermal studies (one key, one supporting) in male C3H/HeJ Mice were conducted to determine the potential of diethylene triamine (DETA) to cause skin tumors. Both high purity and commercial grade were used in these evaluations.  

Key value for chemical safety assessment

Carcinogenicity: via dermal route

Endpoint conclusion
Dose descriptor:
56.3 mg/kg bw/day

Justification for classification or non-classification

Diethylene triamine is not carcinogenic via the dermal route and not classifiable under GHS.

Additional information

Male C3H/HeJ mice were administerd 25 ul of a 5% solution of DETA three times per week throughout their lifetime. The Mean Survival time was 587 and 662 days for the purified and commercial grade DETA. There were no treatment related tumors of the skin in any of the mice. Gross pathology and histologic analysis of kidney, urinary bladder, stomach, liver, skin, thyroids, adrenals, heart, spleen, mesenteric lymph node, bronchi lymph node, pancreatic lymph node, mediastinum, lung prostate, and seminal vesicles did not show any treatment related tumors.