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EC number: 203-865-4
CAS number: 111-40-0
There were no notable pathologic findings in the rats of each
The chronic toxicity of diethylenetriamine (DETA) was studied by
subcutaneous injeciton and by painting on the skin of rats. Inasmuch as
diethylenetriamine has an irritative and corrosive action on the skin,
it was diluted with distilled water for the experiments, 1:10 dilution
was also made for the painting. The animals were kept in pens to observe
the toxic effects of DETA on them during their life spans. After the
animal's death, the histopathological changes produced thereby in the
visceral organs were studied.
The results were obtained as follows:
1.) Four-tenths ml of the DETA diluted solution (1:10) was applied every
day on the back of rats in group C.
2.) The average days of survival was 407 days in group C, and 581 days
for the rats in control group D. The maximum survival day of the rats
among group D was 1010 days.
3.) There were no notable gross pathologic findings in the rats of each
experimental group. The numbers of erythrocytes and leucocytes, the
change of body weight and the numbers of litter were not markedly
different between the rats given DETA and the control.
4.) The histopathological changes produced by the administration of DETA
were obseved mainly in kidney and liver. The damages were noticed in the
rats in group C. Pneumonia, which seemed to be resulted from the
decrease of physical resistance was also observed in both group C and D.
Some slight histopathological changes were observed in both spleen and
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