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EC number: 203-865-4
CAS number: 111-40-0
The purpose of these studies was to evaluate the
allergenic potential and to determine the ability to cause allergic
sensitization of the respiratory tract. To this end, a selective and
step-wise approach was employed using the local lymph node assay (LLNA),
cytokine fingerprinting, and the mouse IgE test. Chemicals that elicited
positive responses in the LLNA test were selected for further analyses
using cytokine fingerprinting to determine whether they provoke in mice
patterns of cytokine production consistent with a potential to cause
respiratory sensitization. The rationale is that experience to date
indicates all chemical respiratory allergens are able to induce positive
responses in the LLNA and in other predictive tests for contact
sensitizing potential. The corollary is that chemicals which failed to
cause LLNA responses lacked the ability to cause sensitization of the
respiratory tract also. The mouse IgE test was used for the
identification of chemicals that had the potential to cause allergic
sensitization of the respiratory tract. The method was based upon the
fact that topical exposure of mice to chemical respiratory allergens
elicits a substantial increase in the total serum
concentration of IgE; a response not observed with chemical contact
allergens believed not to cause respiratory sensitization.
DETA possesses contact allergic potential (positive in
the local lymph node assay but failed to provoke significant cytokine
production as judged by cytokine fingerprinting); however lack of
immunogenicity means that it is not possible to confirm a secure
negative with respect to respiratory sensitizing potential.
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