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EC number: 203-865-4
CAS number: 111-40-0
Repeat dose toxicity studies include a 90-day (subchronic) dietary toxicity study with the dichloride salt of diethylenetriamine (DETA) in Albino Rats and a 7 day oral gavage study in rats and 7 day dietary study.One chronic dermal study in rats was evaluated where DETA was applied throughout the lifetime of the animal One subacute inhalation toxicity study in rats.
DETA-HCL was administered for 90 days in the diet of rats at the follow
concentrations: 0, 1000, 7500, or 15000 ppm which correspond to mean
intake levels of 70, 530, and 1060 mg/kg/day for males; and 80, 620, and
1210 mg/kg/day for females. No treatment related effects related to
clinical signs, gross necropsy, or histopathology were found with any
treatment regardless of sex.
For males in the mid-dose group, treatment related changes were observed
in the following endpoints: decreased body weight or body weight gain,
and an increase in MCV and MCH. For males in the high dose group,
treatment related changes were observed in the following endpoints:
decreased food consumption, decreased body weight or body weight gain,
and an increase in MCV and MCH. For females in the mid-dose, the
following treatment related effects were observed: decreased body weight
or body weight gain, decreased glucose, increased MCV, increased urine
pH, and increased kidney and liver weights. For females in the high dose
group, the follwing treatment related effects were observed, decreased
food consumption, decreased body weight or body weight gain, decreased
glucose, albumin and MCV, and increased liver, kidney and adrenal glands
weights. Based on these findings the NOAEL is 1000 ppm (70 mg/kg/day for
males, 80 mg/kd/day for females). The LOAEL is 7500 ppm (530 mg/kd/day
for males and 620 mg/kg/day for females).
In a chronic dermal study, Wistar rats were administered 0.4 mls of a
100 mg/cc solution of DETA. Five animals/sex/dose were administered 0.4
mls once a day six times per week. The average number of survival days
was 407 days. The body weights of both male and female groups treatment
group were similar to controls. No average weight was given, instead
body weights were represented by a graph with an estimated lifetime
average of 350 gram for males and 250 grams for females upon inspection.
Therefore, the average daily dose was estimated to be 114 mg/kg for
males and 160 mg/kg for females. No treatment related effects were noted
on the numbers of erythrocytes and leucocytes, body weight, numbers of
litters, and histopathology. The NOAEL for chronic dermal application of
DETA was 114 mg/kg.
In a subacute inhalation toxicity study using Alderley Park
specific-pathogen-free rats, the animals were administered 0.55 mg/L of
DETA for 6 hours per day 5 days a week for 3 weeks. No overt signs of
toxicity were noted. Organs appeared normal upon gross pathology.
DETA is not classifiable under GHS. Target organ systemic effects upon
repeat exposure were not observed at oral doses at or below 100
mg/kg/day which is the cut-off value for GHS classification catagory 2.
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