Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-865-4 | CAS number: 111-40-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not applicable
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 957
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- BASF test according to internal SOP
- GLP compliance:
- no
- Remarks:
- Conducted prior to GLP guidelines
Test material
- Reference substance name:
- 2,2'-iminodi(ethylamine)
- EC Number:
- 203-865-4
- EC Name:
- 2,2'-iminodi(ethylamine)
- Cas Number:
- 111-40-0
- Molecular formula:
- C4H13N3
- IUPAC Name:
- bis(2-aminoethyl)amine
- Details on test material:
- - Name of test material (as cited in study report): Diaethylentriamin (as named in study report); Substance ID: VI/236
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: white rabbit
- Details on test animals or test system and environmental conditions:
- No data
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- - Concentration (if solution): 40% and 100%
- Duration of treatment / exposure:
- 1, 5, and 15 min
- Observation period:
- 3 weeks
- Number of animals:
- 2 animals used
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, lutrol concentrated and 50% dilution in water used
- Time after start of exposure: 1, 5, 15 mins
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: necrosis
- Basis:
- animal #1
- Time point:
- other: 15 min
- Remarks on result:
- other: 100% Diethylenetriamine; upon substance removal very strong reddening with begining necrosis
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 15 min
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: 40% of diethylene triamine; No findings
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 15 min
- Reversibility:
- no data
- Remarks on result:
- other: 40% of diethylene triamine; visible erythema
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 and 5 min
- Score:
- 0
- Remarks on result:
- other: 40% of diethylene triamine ; without findings
- Irritation parameter:
- other: necrosis
- Basis:
- animal #1
- Time point:
- other: 15 min
- Remarks on result:
- other: 100% of diethylene triamine; upon substance removal very strong reddening with begining necrosis
- Irritation parameter:
- other: necrosis
- Basis:
- animal #1
- Time point:
- other: Day 1
- Remarks on result:
- other: 100% of diethylene triamine; On day 1 greyish-brownish necrosis
- Irritation parameter:
- other: necrosis
- Basis:
- animal #1
- Time point:
- other: Day 2
- Remarks on result:
- other: 100% diethylenetriamine; On day 2 leather-like blackish-brown crust-formation
- Irritation parameter:
- other: necrosis
- Basis:
- animal #1
- Time point:
- other: 3 weeks
- Reversibility:
- not reversible
- Remarks on result:
- other: 100% Diethylenetriamine; deep scar 3 weeks later
- Irritation parameter:
- other: necrosis
- Basis:
- animal #2
- Time point:
- other: 15 min
- Remarks on result:
- other: 100% Diethylenetriamine; blackish-brown necrosis, bleeding, marginal red swelling
- Irritation parameter:
- other: necrosis
- Basis:
- animal #2
- Time point:
- other: 15 min
- Reversibility:
- no data
- Remarks on result:
- other: 100% of diethylene triamine; blackish-brown necrosis, bleeding, marginal red swelling
- Irritant / corrosive response data:
- Refer to remarks below
- Other effects:
- Refer to remarks below
Any other information on results incl. tables
40% of diethylene triamine
15 min exposure:
1 animal without findings, one animal visible erythema
5 min exposure: without findings
1 min exposure: without findings
100% of diethylene triamine:
15 minutes exposure:
1st animal: upon substance removal very strong reddening with begining necrosis. On day 1 greyish-brownish necrosis; on day 2 leather-like blackish-brown crust-formation with remaining deep scar 3 weeks later
2nd animal: blackish-brown necrosis, bleeding, marginal red swelling
5 min of exposure:
1st animal: upon substance removal: reddening, spotted necrosis; on day 1 grey-brownish necrosis; on day 2 leather-like blackish-brown crust formation with remaining deep deep scar 3 weeks latter.
2nd animal ; upon substance removal; Tan necrosis, bleeding, marginal red swellling; on day 1 anaemic necrosis with marginal reddening; 8 day hard crust formation with remainning scar after 3 weeks
1 min of exposure: upon substance removal slight reddening, partly necrotic wtih marginal reddening; on day 1 slight reddening and pea sized necrosis; On day 2 spotted reddening with pea-sized necrosis; on day 8 spotted crusts with remaining scars.
Applicant's summary and conclusion
- Conclusions:
- A 15 minute exposure to DETA resulted in necrosis in two of two rabbits.
- Executive summary:
The skin irritation potential of DETA was examined. A 15 minute exposure to DETA resulted in necrosis in two of two rabbits.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
Sellel veebilehel kasutatakse küpsiseid, et tagada lehe parim kasutus.