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EC number: 203-865-4 | CAS number: 111-40-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not applicable
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 957
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- BASF test according to internal SOP
- GLP compliance:
- no
- Remarks:
- Conducted prior to GLP guidelines
Test material
- Reference substance name:
- 2,2'-iminodi(ethylamine)
- EC Number:
- 203-865-4
- EC Name:
- 2,2'-iminodi(ethylamine)
- Cas Number:
- 111-40-0
- Molecular formula:
- C4H13N3
- IUPAC Name:
- bis(2-aminoethyl)amine
- Details on test material:
- - Name of test material (as cited in study report): Diaethylentriamin (as named in study report); Substance ID: VI/236
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: white rabbit
- Details on test animals or test system and environmental conditions:
- No data
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- - Concentration (if solution): 40% and 100%
- Duration of treatment / exposure:
- 1, 5, and 15 min
- Observation period:
- 3 weeks
- Number of animals:
- 2 animals used
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, lutrol concentrated and 50% dilution in water used
- Time after start of exposure: 1, 5, 15 mins
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: necrosis
- Basis:
- animal #1
- Time point:
- other: 15 min
- Remarks on result:
- other: 100% Diethylenetriamine; upon substance removal very strong reddening with begining necrosis
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 15 min
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: 40% of diethylene triamine; No findings
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 15 min
- Reversibility:
- no data
- Remarks on result:
- other: 40% of diethylene triamine; visible erythema
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 and 5 min
- Score:
- 0
- Remarks on result:
- other: 40% of diethylene triamine ; without findings
- Irritation parameter:
- other: necrosis
- Basis:
- animal #1
- Time point:
- other: 15 min
- Remarks on result:
- other: 100% of diethylene triamine; upon substance removal very strong reddening with begining necrosis
- Irritation parameter:
- other: necrosis
- Basis:
- animal #1
- Time point:
- other: Day 1
- Remarks on result:
- other: 100% of diethylene triamine; On day 1 greyish-brownish necrosis
- Irritation parameter:
- other: necrosis
- Basis:
- animal #1
- Time point:
- other: Day 2
- Remarks on result:
- other: 100% diethylenetriamine; On day 2 leather-like blackish-brown crust-formation
- Irritation parameter:
- other: necrosis
- Basis:
- animal #1
- Time point:
- other: 3 weeks
- Reversibility:
- not reversible
- Remarks on result:
- other: 100% Diethylenetriamine; deep scar 3 weeks later
- Irritation parameter:
- other: necrosis
- Basis:
- animal #2
- Time point:
- other: 15 min
- Remarks on result:
- other: 100% Diethylenetriamine; blackish-brown necrosis, bleeding, marginal red swelling
- Irritation parameter:
- other: necrosis
- Basis:
- animal #2
- Time point:
- other: 15 min
- Reversibility:
- no data
- Remarks on result:
- other: 100% of diethylene triamine; blackish-brown necrosis, bleeding, marginal red swelling
- Irritant / corrosive response data:
- Refer to remarks below
- Other effects:
- Refer to remarks below
Any other information on results incl. tables
40% of diethylene triamine
15 min exposure:
1 animal without findings, one animal visible erythema
5 min exposure: without findings
1 min exposure: without findings
100% of diethylene triamine:
15 minutes exposure:
1st animal: upon substance removal very strong reddening with begining necrosis. On day 1 greyish-brownish necrosis; on day 2 leather-like blackish-brown crust-formation with remaining deep scar 3 weeks later
2nd animal: blackish-brown necrosis, bleeding, marginal red swelling
5 min of exposure:
1st animal: upon substance removal: reddening, spotted necrosis; on day 1 grey-brownish necrosis; on day 2 leather-like blackish-brown crust formation with remaining deep deep scar 3 weeks latter.
2nd animal ; upon substance removal; Tan necrosis, bleeding, marginal red swellling; on day 1 anaemic necrosis with marginal reddening; 8 day hard crust formation with remainning scar after 3 weeks
1 min of exposure: upon substance removal slight reddening, partly necrotic wtih marginal reddening; on day 1 slight reddening and pea sized necrosis; On day 2 spotted reddening with pea-sized necrosis; on day 8 spotted crusts with remaining scars.
Applicant's summary and conclusion
- Conclusions:
- A 15 minute exposure to DETA resulted in necrosis in two of two rabbits.
- Executive summary:
The skin irritation potential of DETA was examined. A 15 minute exposure to DETA resulted in necrosis in two of two rabbits.
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