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EC number: 203-865-4
CAS number: 111-40-0
The application of undiluted diethylene tramine to the
clipped skin of the rabbit trunk resulted in an LD50 of 1.09 (0.95 to
1.24) ml/kg calculated by the method of Thompson. Immediate erythema,
followed by necrosis and finally a leathery scab resulted from the
direct action of the material on the skin. In animals that died, the
lungs were often congested and sometimes hemorrhagic; the kidneys showed
considerable gross damage including a pitted appearance of the surface
and subcapsular hemorrhage. The stools of survivors were watery and
sometimes blood-tinged. With a 10% aqueous dilution the corrosive action
on the skin was eliminated and none of 6 rabbits succumbed to a dosage
of 2.0 gm/kg (20 ml/kg or the 10% dilution). One of 6 rabbits' died an
unexplained death at 1.0 gm/kg. All lost weight save one, which gained
only 4- grams. This demonstrates that the toxicity by skin absorption is
enhanced by the corrosive action of the undiluted compound as the LD50
for a 10% dilution would be above 4 gm/kg.
The acute dermal toxicity of DETA was examined. The LD50 for the
undiluted compound in the rabbit-skin penetration test is 1.09 (0.95 to
1.24) ml/kg. Using the density value of 958.6 kg/m3(IUCLID
section 4.4) this corresponds to 1045 mg/kg (range 910 mg/kg to 1190
mg/kg). Severe skin damage resulted from the undiluted
As a 10% dilution in water the corrosive action is practically
eliminated and 2.0 gm/kg (20 ml/kg of the 10% dilution) is not lethal,
demonstrating that skin damage abets skin penetration.
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