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EC number: 203-865-4
CAS number: 111-40-0
No additional information available.
Fischer 344 rats were exposed to DETA in the diet at concentrations of
0, 1000, 7500, or 15000 ppm for 90 days. Group sizes were 30/sex for the
high dose and control groups, and 20/sex for the intermediate and low
dose groups. The doses corresponded to approximate mean intake levels of
70, 530, and 1060 mg/kg/day for the males and 80, 620, and 1210
mg/kg/day for the females of the 1000, 7500, and 15000 ppm groups,
respectively. Following the exposure period, ten animals from each of
the control and high dose groups were observed for 4 weeks during a
recovery phase. No treatment-related clinical signs, gross necropsy
findings, or histopathologic findings were observed for either sex at
any dose level. No alterations related to treatment in other
measurements including food consumption, body weights, ophthalmologic
findings, hematology, serum clinical chemistry, urinalysis, or organ
weights were observed in the 1000 ppm group for either sex.
Several treatment-related effects on in-life, clinical pathology, and
organ weight measurements were observed for the 7500 and 15000 ppm
groups through the 13-week treatment period. Decreases in food
consumption were observed intermittently throughout the dosing period in
males and females at the high dose. Dose-related decreases in body
weight or weight gain were observed for both sexes in the mid and high
dose groups. Minimal changes in clinical pathology measurements that
were potentially treatment-related included: for the males, increased
MCV and MCH in the high and mid dose groups, and for the females,
decreased glucose and albumin, and increased MCV in the high dose group,
and similar changes in glucose and MCV in the mid dose group. In
addition, increased urine pH in the females from the high and mid dose
groups, possibly associated with an increase in kidney weight and/or
excretion of the test material, was observed after 13-weeks of exposure.
A treatment-related increase in kidney weight was observed in the female
rats treated with 7500 or 15000 ppm DETA. In addition, liver (mid and
high dose groups) and adrenal (high dose group only) weight increases in
the females may have been a result of treatment. No other statistically
significant changes in any measurements were attributed to direct
toxicity of DETA at 7500 or 15000 ppm dietary concentrations.
During the recovery period, female rat food consumption was greater than
the concurrent control group and body weights returned to control
levels. Male body weights remained lower than the controls throughout
the recovery period. The majority of other alterations remained affected
after the 4-week period.
In conclusion, dietary exposure of Fischer 344 rats to 7500 or 15000 ppm
of the dihydrochloride salt of diethylenetriamine resulted in
dose-related systemic toxicity. In addition, the majority of the
changes, particularly in male rats, did not completely recover over a
4-week post-dosing period. The no observable effect level for this
species and strain over the 90-day test period was 1000 ppm.
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