Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 205-633-8 | CAS number: 144-55-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
No data on reproduction toxicity were available. However, based on the normal physiological role of sodium and bicarbonate no toxicity on mammalian reproduction is expected. No further study is considered necessary for this endpoint.
Effects on developmental toxicity
Description of key information
An oral developmental study was performed in 3 species (mouse, rat and rabbit). In all three species no maternal or teratogenic effects were noted, and NOAEL 's were above highest dose given.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 340 mg/kg bw/day
Additional information
Sodium bicarbonate did not induce developmental effects when administered orally at the following doses: 580 mg/kg bw (mice), 340 mg/kg bw (rats) and 330 mg/kg bw (rabbits). Furthermore the substance will usually not reach the foetus when the exposure to sodium bicarbonate is sufficiently low, as it does not become systemically available.
[partly taken from OECD SIDS on sodium bicarbonate (2002), pg.18]
Justification for classification or non-classification
Based on the available information, the substance does not need to be classified according to CLP Regulation (EC) No 1272/2008.
Additional information
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