Registration Dossier
Registration Dossier
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EC number: 205-633-8 | CAS number: 144-55-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
No data on reproduction toxicity were available. However, based on the normal physiological role of sodium and bicarbonate no toxicity on mammalian reproduction is expected. No further study is considered necessary for this endpoint.
Effects on developmental toxicity
Description of key information
An oral developmental study was performed in 3 species (mouse, rat and rabbit). In all three species no maternal or teratogenic effects were noted, and NOAEL 's were above highest dose given.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 340 mg/kg bw/day
Additional information
Sodium bicarbonate did not induce developmental effects when administered orally at the following doses: 580 mg/kg bw (mice), 340 mg/kg bw (rats) and 330 mg/kg bw (rabbits). Furthermore the substance will usually not reach the foetus when the exposure to sodium bicarbonate is sufficiently low, as it does not become systemically available.
[partly taken from OECD SIDS on sodium bicarbonate (2002), pg.18]
Justification for classification or non-classification
Based on the available information, the substance does not need to be classified according to CLP Regulation (EC) No 1272/2008.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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