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EC number: 205-633-8 | CAS number: 144-55-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- In the OECD SIDS on sodium bicarbonate (2002) a similar reliability was assigned.
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 72-2 (Aquatic Invertebrate Acute Toxicity Test)
- Deviations:
- yes
- Remarks:
- Alkalinity in the controls were not measured at test initiation, but at test termination
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Test organisms (species):
- Daphnia magna
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Nominal and measured concentrations:
- - Nominal/ measured concentrations in mg A.I./ L
Nominal: 780 Mean Measured (SD):630 (57)
Nominal: 1300 Mean Measured (SD):1100 (81)
Nominal: 2200 Mean Measured (SD):1800 (190)
Nominal: 3600 Mean Measured (SD):3100 (280)
Nominal: 6000 Mean Measured (SD):5400 (400) - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 3 100 mg/L
- Nominal / measured:
- meas. (not specified)
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 4 100 mg/L
- Nominal / measured:
- meas. (not specified)
- Basis for effect:
- mobility
- Reported statistics and error estimates:
- Moving average angle analysis, probit analysis and nonlinear interpolation with 95% confidence intervals calculated by binominal probability.
METHOD OF CALCULATION: the 24-, 48-, 72- and 96-hour median LC50 values were estimated from derived mortality data at the measured concentrations using the described statistical methods which were available in a computer programme. If two or more statistical methods produced acceptable results, then the method which yielded the smallest 95% confidence interval was selected. - Conclusions:
- 48-hr acute flow-through test, Daphnia magna, showed a NOEC of 3,100 mg/l and a LC50 of 4,100 mg/l.
- Executive summary:
A study was conducted exposing for 48-hr flow-through test the water flea, Daphnia magna, to NaHCO3 at concentration ranging from 780 to 6,000 mg/L, following the EPA OPP 72-2 “Aquatic Invertebrate Acute Toxicity Test” guideline. Results showed a NOEC of 3,100 mg/l and a LC50 of 4,100 mg/l.
Reference
- Concentration / response curve:
Mean percentage mortality (of vessel A and B) after 96 hours:
Control: 5 %
630 mg A.I./L: 0 %
1100 mg A.I./L: 0 %
1800 mg A.I./L: 5 %
3100 mg A.I./L: 0 %
5400 mg A.I./L: 100 %
- Effect concentration vs. test substance solubility: Not reported
- Other effects: Not reported
RESULTS CONTROL: No effects
Description of key information
Only one study was performed by GLP standard (Putt, 1993) is available and so it was chosen as key study. Putt (1993) studied, in a 48-hr acute flow-through test, Daphnia magna exposed to NaHCO3at concentration ranging from 780 to 6,000 mg/L, following the EPA OPP 72-2 “Aquatic Invertebrate Acute Toxicity Test” guideline. Results showed a NOEC of 3,100 mg/l and a LC50 of 4,100 mg/l.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 4 100 mg/L
Additional information
Two reliable (K 2) studies (Hoke et al., 1992 and Mount et al.,1997) reported in the OECD SIDS (2002) on sodium bicarbonate, exposed the cladocera, Daphnia magna and Ceriodaphnia sp, for 48h to NaHCO3. Results showed a EC50 for immobilization of 1,268-1,640 mg/l and 1,020-1,268 mg/L, respectively.
Furthermore, a reliable publication (Harper et al., 2014) was available reporting data on 5 different invertebrates: the chironomid Chironomus dilutus (7 -14 dph); the worm Tubifex tubifex (adults); the amphipod Hyalella azteca (adults); the freshwater mussel Lampsilis siliquoidea (newly transformed juveniles) and water flea Ceriodaphnia dubia (neonates). Test were conducted following the EPA guideline 821/R-02/012 “Methods for measuring the acute toxicity of effluents and receiving waters to freshwater and marine organisms, 5th ed”, with the exception of ASTM International E2455-06 “Standard guide for conducting laboratory toxicity tests with freshwater mussels ”for experiments with mussels. Experiments were run in 2 different medium, reconstituted Tongue river water and reconstituted Powder river water for all the species, with exception of test with mussels which were run only in reconstituted Tongue river water. Results showed a LC50 ranging from 989 to 8,014 mg/L NaHCO3, depending on the species and the medium used.
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