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EC number: 205-633-8
CAS number: 144-55-8
The intraperitoneal injection of an unknown concentration ofsodium [14C] bicarbonate into CFW mice was followed byassays (after 24 and 48 hrs and 1, 2, 4 and 12 weeks) ofblood, spleen, liver, kidneys, lungs, brain, jejenum,muscle, skin, hair and long bones. More than 90% of thetotal radioactivity injected was lost via the respiratoryroute in one hour. At 24 hrs, most of the radioactivity inthe blood was in noncarbonate form. Specific activity inlong bones parallelled that in the blood for up to 12 weeks.The radioactivity of the compound injected into a pregnantmouse was fixed in the foetal tisssues more rapidly than inthe maternal tissues. Variable and transient responses in erythrocyte counts andhemoglobin levels in mice to orally administered sodiumbicarbonate was reported.
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