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EC number: 205-633-8
CAS number: 144-55-8
In accordance with Section 1 of REACH
Annex XI, testing does not appear scientifically necessary. None of the
mutagenicity tests were performed according to guidelines. However, all
the results were negative and more or less well documented. Furthermore,
sodium bicarbonate is naturally present in cells and the structure does
not indicate a genotoxic potential. Therefore, sodium bicarbonate is
considered to be not genotoxic. Moreover, is the substance already
present in the tissue culture media of the in vitro test systems for
genetic toxicity testing, and needed for normal function of the cells in
culture. Testing sodium bicarbonate in vitro will affect the
cellular homeostasis due to osmolarity and/or pH of the culture medium
which might give rise to a specific effects.
[partly taken from
OECD SIDS on sodium bicarbonate (2002), pg. 17]
Short description of key information:
An Ames study using S. typhimurium, TA 92, 94, 98, 100, 1535, 1537
Endpoint Conclusion: No adverse effect observed (negative)
Based on the available
information, the substance does not need to be classified according
Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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