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EC number: 205-633-8 | CAS number: 144-55-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Remarks:
- Taken from OECD SIDS on Sodium bicarbonate (2002), where a similar reliability was assigned.
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of Bicarbonate, Citrate, and Phosphate Loading on Performance
- Author:
- Horswill, C.A.
- Year:
- 1 995
- Bibliographic source:
- Int. J. Sport Nutr. suppl., S111-S119
Materials and methods
- Principles of method if other than guideline:
- other
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium hydrogencarbonate
- EC Number:
- 205-633-8
- EC Name:
- Sodium hydrogencarbonate
- Cas Number:
- 144-55-8
- Molecular formula:
- CH2O3.Na
- IUPAC Name:
- sodium hydrogen carbonate
- Details on test material:
- SOURCE: Not reported.
PURITY: Not reported.
IMPURITY/ADDITIVE/ETC.:Not reported.
ANY OTHER INFORMATION: Not reported.
Constituent 1
Test animals
- Species:
- human
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: oral
- Vehicle:
- other: solution or capsule
- Frequency of treatment:
- single dose or several doses taken over several hours.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.1-0.5 g/kg
Basis:
- Control animals:
- not specified
- Details on study design:
- Observation period: no data
Results and discussion
Any other information on results incl. tables
This paper reviews the theoretical mechanisms whereby bicarbonate may enhance physical performance at high intensities. Ingested bicarbonate elevates the bicarbonate concentration in the extracellular space, but not the intracellular space. The mechanism by which bicarbonate loading exerts its influence may be through the elevation of the extracellular bicarbonate concentrations, which then increases rate of efflux of H+ from the intracellular space.
Others claim that the ingested sodium changes the strong-ion difference, and that this change, not the bicarbonate per se, produces the increase in blood buffering capacity. The typical protocol employed to administer a sodium bicarbonate buffer was a dose of 0.1-6.0 mmol/kg given as a single oral dose (solution or capsule), either as one dose 1 hr before performance, or as repeated doses taken over several hours before performance. A positive correlation was found between bicarbonate dosage and the extent of improvement in performance, using data generated from mean values reported in the literature. 0.3 g/kg is the apparent minimum effective dose. The ergogenic effects of bicarbonate appear to be most consistent either when exercise protocols involve repeated sprints that are interspersed with short recovery periods or when protocols commence at submaximal intensities, becoming progressively more difficult, and culminate at near-maximum levels. During a performance the blood bicarbonate system becomes the primary mechanism for buffering H+ only after the subject reaches the anaerobic threshold. Despite the existing results it hasn't yet been conclusively demonstrated that buffers can improve sport performance.
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