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EC number: 205-633-8
CAS number: 144-55-8
The toxicokinetics of sodium bicarbonate have been described
already on page 13 of the OECD SIDS dossier (2002). Please find
hereafter the text:
The major extracellular buffer in the blood and the interstitial
fluid of vertebrates is the bicarbonate buffer system, described by the
+ CO2 <=> H2CO3
<=> H++ HCO3-
Carbon dioxide from the tissues diffuses rapidly into red blood
cells, where it is hydrated with water to form carbonic acid. This
reaction is accelerated by carbonic anhydrase, an enzyme present in high
concentrations in red blood cells. The carbonic acid formed dissociates
into bicarbonate and hydrogen ions. Most of the bicarbonate ions diffuse
into the plasma. Since the ratio of H2CO3
to dissolved CO2 is constant at
equilibrium, pH may be expressed in terms of bicarbonate ion
concentration and partial pressure of CO2 by
means of the Henderson-Hasselbach equation: pH = pk + log[HCO3-]/aPCO2
The blood plasma of man normally has a pH of 7.40. Should the pH
fall below 7.0 or rise above 7.8, irreversible damage may occur.
Compensatory mechanisms for acid-base disturbances function to alter the
ratio of HCO3-
to PCO2, returning the pH of the
blood to normal. Thus, metabolic acidosis may be compensated for by
hyperventilation and increased renal absorption of HCO3-.
Metabolic alkalosis may be compensated for by hypoventilation and the
excess of HCO3-
in the urine (Johnson and Swanson, 1987). Renal mechanisms are
usually sufficient to restore the acidbase balance (McEvoy, 1994). The
uptake of sodium, via exposure to sodium bicarbonate, is much less than
the uptake of sodium via food. Therefore, sodium bicarbonate is not
expected to be systemically available in the body. Furthermore it should
be realised that an oral uptake of sodium bicarbonate will result in a
neutralisation in the stomach due to the gastric acid.
the publication of the OECD SIDS dossier no additional relevant studies
on toxicokinetics were found.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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