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EC number: 205-633-8
CAS number: 144-55-8
The study assessed the carcinogenic potential of OPP-Na and OPP in
combination with NaHCO3. NaHCO3 alone did not have a carcinogenic effect
on the urinary bladder of rats. Papillary or nodular hyperplasia and
papilloma incidence did not differ from the control group incidence.
MORTALITY AND TIME TO DEATH: The percentage of survival in week 104 was:
NaHCO3-exposed animals: 84% (26/31); control group: 73% (22/30). Time of
death is not reported.
BODY WEIGHT GAIN: The final body weight was significantly lower in
all treated groups than in the control group.
URINALYSIS: The urinary Na+ concentrations increased significantly
with NaHCO3 exposure, compared to the control group 7. Potassium levels
were increased significantly compared to the control group. NaHCO3
exposure also caused significantly elevated urinary pH concentrations.
ORGAN WEIGHTS: The relative weight (organ/body weight %) of
kidneys and liver was significantly increased compared to the control.
GROSS PATHOLOGY: NaHCO3-exposed animals did not have a significant
increase in the number of tumours, in comparison to the control group.
TIME TO TUMOURS: The first bladder tumour was found in a rat that
died in week 49. It is not known how many rats survived the full
experimental period of 104 weeks.
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