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EC number: 205-633-8
CAS number: 144-55-8
- One female dosed with 4000 mg/kg died.- Time of death: The animal died within 24 hours of administration.- Number of deaths at each dose: 1/5 females dosed with 4000 mg/kg died.
All the surviving animals gained weight during the postexposure observation period. The clinical signs of toxicity included soft stool, hypoactivity, dark-stained urogenital area. The surviving animals returned to a normal appearance by day 2. Of the females dosed with 3500mg/kg, 4/5 had soft stool, 1/5 had a dark-stained urogenital area and 1/5 exhibited hypoactivity, within the first day.
Among the females dosed with 4000 mg/kg, 1/5 had soft stool and 1/5 was hypoactive during the first day.Among the males dosed with 4500 mg/kg, 1/5 had soft stool and 1/5 was hypoactive during the first day.
In the female that died on day 0, a single erosion was found in the glandular mucosa of the stomach near the pylorus. An enlarged pelvis was present in the right kidney of a male given 3000 mg/kg, both mandibular lymph nodes were enlarged in a male given 4000 mg/kg, and multiple opaque areas were on the parietal surface of the spleen in a male and a female given 4000 mg/kg.
POTENTIAL TARGET ORGANS: Not reported.
SEX-SPECIFIC DIFFERENCES: Not reported.The no observable adverse effects level (NOAEL) is 4,000 mg/kg in males and 3,000 mg/kg in females.
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