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EC number: 203-002-1
CAS number: 102-06-7
In an avian study performed on three species of song bird
at a limit concentration of 100 mg/kg, no effects were observed. Indeed,
DPG showed no acute toxicity to 3 song bird species:Agelaius
phoeniceus, Sturnus vulgaris and Passer domesticus.
After a 2-6 weeks adaptation phase, wild-caught birds received a single
oral administration of the compound dissolved in propylene glycol. The LD50
for all three species was above the highest administrated dose of
100 mg/kg bw.
A terrestrial plant study conducted on monocotyledons and
dicotyledons did not show a high level of concern for DPG in these
species (Brassica rapa: EC50 = 358 mg/kg; Avena sativa:
EC50 = 1169 mg/kg). This study is used for PNEC derivation.
We applied the EPM strategy to soil risk
assessment, following the rules set out in the integrated testing
strategy (ITS) detailed insection R.7.11.6., Chapter R.7c
of the ECHA Guidance on information requirements and chemical safety
assessment (version 2.0, November 2014). Only one relevant
terrestrial toxicity datum is available for derivation of a PNECsoil.
Therefore, a “soil hazard category” was assigned to DPG. DPG is not very
toxic to aquatic organisms and is readily biodegradable. In addition,
both partition and adsorption coefficients (both inferior to 3) allows
considering DPG as not very adsorptive. DPG falls therefore within the
scheme of “Hazard category 1”, which states that only the EPM method is
required for the screening assessment. When PEC/PNECscreen is inferior
to 1, then “no toxicity testing for soil organisms need to be done”, as
stated in the R.7c Guidance. The new RCRs derived with both the EPM
method and the available toxicity datum to plants are inferior to 1 for
the terrestrial compartment. This information is presented in the
updated CSA. Therefore, following the rules set out insection R.7.11.6.,
Chapter R.7c of the ECHA Guidance on information requirements and
chemical safety assessment (version 2.0, November 2014), and in
accordance with the REACh regulation EC 1907/2006 annexes IX and X,
section 9.4, column 2, no additional testing on terrestrial organism is
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