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EC number: 203-002-1
CAS number: 102-06-7
A long-term study (34 days) was conducted on Pimephales promelas eggs (OECD 210 guidelines, semi-static method). NOEC for both hatching and larval survival rates were 1.3 mg/L
DPG (1,3-Diphenylguanidine) has been shown to be toxic to
fish and algae and harmful to daphnia in several acute studies (fish :
96 h LC50 = 4.2-11 mg/l; algae : 72 h EC50 = 7.5 mg/l; 96 h EC50 = 1.7
mg/l; daphnid : 24 h EC50 = 73.6 mg/l; 48 h EC50 = 17mg/l). The PNEC can
be determined using the NOECs from the algae (0.3 mg/l) and daphnid
chronic 21 d (0.6 mg/l) studies (excluding the EbC50 results), by
applying an uncertainty factor of 50. The resulting PNEC would be 6
µg/l. In order to refine this PNEC value for the aquatic compartment we
performed a long-term test on fish (following OECD 210 guidelines).
In brief, Pimephales promelas eggs were exposed to
graded concentrations of DPG for 34 days (0.041, 0.13, 0.41, 1.3 and 4.2
mg/L) under semi-static conditions. After 8 days, all larvae had
hatched. Both hatching and larval survival rates were recorded daily. At
the end of the test, all surviving larvae were weighted and measured. No
significant effect were observed on fish length and weight. The NOEC for
both hatching and larval survival was 1.3 mg/L. EC50 for larval survival
was 1.8 mg/L.
From this result, the retained NOEC will be 0.3 mg/L
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