Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-002-1
CAS number: 102-06-7
In an oxygen consumption test following OECD guideline 209, with unadapted activated sludge from a laboratory plant as inoculums, an EC50 -3 hours of 147 mg/l was estimated (79 -208 mg/l).
Tomlinson et al. (1966) investigated the effect of
1,3-diphenylguanidine on the nitrification process in municipal waste
waters. They incubated purified activated sludge (dw = 1350 - 1700 mg/l)
for 2 - 4 hours in residential waste water that was free of suspended
particles in a shake culture (25°C; pH= 7.6 - 7.8) at various test
compound concentrations. The nitrification rate was determined
quantitatively by colorimetric measurement of the NO2- and NO3-
concentrations. The effective concentration for decreasing the
nitrification rate by 75% in the first stage (NH4 + =>NO2 -) compared to
the control was estimated at 50 mg/l (highest tested ineffective
In vitro studies on cell homogenates of Escherichia coli
B showed an inhibitive effect of 1,3 -diphenyl guanidine on specific
steps of protein biosynthesis, due to non competitive inhibition of the
phenylalanyl-tRNA synthetase. 50% inhibition occured at a molar
inhibitor/amino acid ratio of 3.2. At an L-phenylalanine concentration
of 0.3 mmol/l (49.5 mg/l) this corresponds to an EC50 of 202.8 mg/l 1,3
Lastly, in the oxygen consumption test following OECD
guideline 209, with unadapted activated sludge from a laboratory plant
as inoculums, an EC50 -3 hours of 147 mg/l was estimated (79 -208 mg/l).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Esta web utiliza cookies para mejorar su experiencia de navegación en nuestros sitios web.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again