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EC number: 203-002-1
CAS number: 102-06-7
A terrestrial plant study conducted on monocotyledons and dicotyledons did not show a high level of concern for 1,3 -diphenylguanidine in these species (Brassica rapa: EC50 = 358 mg/kg; Avena sativa: EC50 = 1169 mg/kg).
Studies on the influence of urea derivatives on the
germination rate of higher plants were carried out on lettuce seeds (Lactuca
sativa) by Kefford et al. (1965). The seedlings were first
preincubated for 24 hours in the absence of light on pre-treated filter
paper at 25°C (negative control 1 ml water; positive control 1 ml
germination-inducing kinetin solution, 5E-05 mol/l) and then illuminated
with red light. The lighting intensity was selected to achieve a 20%
germination rate in the negative controls; in the positive controls the
germination rate was 85 -95%. The germination rate was determined after
a further 48 -hour incubation in the absence of light.
At 0.21 mg/l 1,3 -diphenylguanidine did not affect the
germination rate compared to the negative controls. At a
concentration of 2.1 mg/l it induced a germination rate of 57 % and
at 21.1 mg/l of 104% compared to the positive controls. A parallel
investigation showedno influence on the cell division activity to
Bempong & McCoy (1972) studied the effect of 1,3
-diphenylguanidine on the mitotis cycle of root cells of fiels beans (Vicia
faba). The cells were pre-treated for three hours with 0.02%
colchicine, transferred for 5, 10 or 16 hours to aerated water, exposed
to the tested substance (1 -10 mg/l 1,3 -diphenylguanidine) under
intensive aeration for 30 -minutes and finally, after thorough washing,
transferred to aerated water for 5 -29 hours. A concentration-related
reduction in the mitotis index was observed (0.43 - 9.48; control 13.94)
and the appearance of chromosome aberrations in 5 -55% of the cells
These two studies have been considered as not relevant
for the hazard assessment due to their unsuitable test systems and their
methodological deficiences. In a more recent terrestrial plant study
conducted on monocotyledons and dicotyledons did not show a high level
of concern for 1,3 -diphenylguanidine in these species (Brassica
rapa:EC50 = 358 mg/kg;Avena sativa: EC50 = 1169 mg/kg).
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