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EC number: 203-002-1
CAS number: 102-06-7
In accordance with column 2 of REACH Annex X, testing on
long-term or reproductive toxicity to birds (required in section 9.6.1.)
should be carefully considered taking into account the large mammalian
dataset that is usually available at this tonnage level.
The study on birds does not need to be conducted as
sufficient reliable data is available from the mammalian data set. So,
any need for testing should be carefully considered taking into account
the large mammalian dataset that is usually available at this tonnage
level. Nevertheless, this endpoint allows considering potential
secondary poisoning issues to birds following chronic exposure to
1,3-diphenylguanidine via the fish and earthworm food chains.
1,3-diphenylguanidine and its salts are not expected to bioaccumulate in
fish/earthworm tissues. Moreover, 1,3-diphenylguanidine is not expected
to be persistent in aquatic and terrestrial media.Considering all those
elements one can safely conclude that secondary poisoning is not
expected as birds will not be exposed to 1,3-diphenylguanidine via food
On the top of that, a study on 1,3 -diphenylguanidine
showed no acute toxicity to 3 song bird species: Agelaius
phoeniceus, Sturnus vulgaris and Passer domesticus.
After a 2 -6 weeks adaptation phase, wild-caught birds received a single
oral administration of the compound dissolved in propylene glycol. The LD50
for all three species was above the highest administrated dose of
100 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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