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EC number: 215-572-9
CAS number: 1332-65-6
Table 1. Summary of Group Mean Data.
Treatment group (mg/kg x2)
Sampling point (hours)
Mean ratio PCE/NCE
Group mean frequency of micronucleated PCE (per 1000)
Per treatment group
Vehicle control (purified water)
447 (copper sulphate pentahydrate)
Positive control (CPA – single dose only)
Copper II sulphate pentahydrate was assayed in vivo in a mouse
bone marrow micronucleus test at a single dose level of 447 mg/kg
(113.76 mg Cu/kg) for two consecutive days to groups of 5 male and 5
female mice sacrificed 24 or 48 hours after the second administration.
Both negative (purified water) and positive controls (cyclophosphamide)
were included in the study. The study was conducted according to EEC
Annex V test B12 guidelines and in compliance with GLP.
Mice treated with copper II sulphate pentahydrate exhibited frequencies
of micronucleated polychromatic erthrocytes which were similar to
vehicle controls at all sampling times. There were no instances of
statistically significant increases in micronucleus frequency for any
group receiving the test chemical at either sampling point.
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