Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-572-9
CAS number: 1332-65-6
A GLP-compliant study was conducted in accordance with the requirements
of EC Guideline B.3 and OECD 402. Dicopper chloride
trihydroxide was used. Five male and five female
Sprague-Dawley rats weighing 199 to 320 g were housed in groups of up to
five by sex and acclimatised prior to dosing. A dose
level of 2000 mg/kg bw was applied on a surgical gauze patch (5 x 5 cm)
moistened with distilled water to an area of intact shaven skin,
approximately 25 cm2 in size (approximately 10% of the total body
surface area), of each rat on Day 1. The patch
was held in place with non-irritating occlusive tape wrapped around the
trunk of the animal. After 24 hours, the dressings
were removed and the skin wiped with dampened tissue to remove residual
test substance. Animals were observed for
treatment-related clinical signs frequently on the day of administration
and once daily for the 14‑day post-dosing period. Animals
were weighed prior to treatment and after 7 days (Day 8) and 14 days
(Day 15). Decedents and animals surviving to
14 days were subject to gross necropsy.
There were no mortalities. The only clinical sign
recorded was a red nasal discharge in four of the males four hours after
dosing. All animals showed acceptable weight gain
during the study. No gross findings were recorded at
The acute dermal LD50 of dicopper chloride trihydroxide to the rat was
greater than 2000 mg/kg bw for males and females. Dicopper
chloride trihydroxide is not classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Esta web utiliza cookies para mejorar su experiencia de navegación en nuestros sitios web.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again