Dicopper chloride trihydroxide

Endpoint summary

Additional information

Acute oral toxicity:

All available studies were GLP-compliant and conducted in accordance with internationally accepted guidelines. Studies in the rat gave LD50 values between 200 and 2000 mg/kg bw. However, the most sensitive result was obtained in the mouse (Haynes, 1998), with an acute oral LD50 of 299 mg/kg bw for the sexes combined. It is therefore concluded that the following classification applies to dicopper chloride trihydroxide on the basis of acute oral toxicity:

• Classification according to Directive 67/548/EEC: Harmful (Xn). R22, Harmful if swallowed.
• Classification according to CLP/GHS: Acute Tox. 4, H301: Toxic if swallowed.

Acute inhalation toxicity:

The most sensitive LC50 value of 2.83 mg/l air was obtained in male rats following a 4 hour exposure (Wesson, 2003). On this basis, it is concluded that the following classification applies to dicopper chloride trihydroxide on the basis of acute inhalation toxicity:

• Classification according to Directive 67/548/EEC: Harmful (Xn). R20, Harmful by inhalation.
• Classification according to CLP/GHS: Acute Tox. 4, H332: Harmful if inhaled.

Acute dermal toxicity:

Four GLP-compliant studies conducted in accordance with internationally accepted guidelines are available for acute dermal toxicity. In each case the LD50 value obtained in both sexes was > 2000 mg/kg bw. On this basis is is concluded that dicopper chloride trihydroxide is not classified on the basis of dermal toxicity.