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EC number: 215-572-9
CAS number: 1332-65-6
High quality chronic single-species NOEC/(L(E)C10 values are available for 10 freshwater fish species. A chronic fish Biotic Ligand Model was developed for 2 fish speices. These NOECS and the chronic fish Biotic ligand models (BLM) are carried forward to the risk characterisation.
High quality chronic single-species NOEC/(L(E)C10 values are available for 2 marine fish species. These NOECS are carried forward to the risk characterisation.
NOECS for freshwater fish:
High quality chronic
NOEC/(L(E) C10 values are available for 10 species: Ictalurus
punctatus, Oncorhynchus kisutch, Oncorhynchus mykiss, Salvelinus
fontinalis,Pimephales promelas, Pimephales notatus, Perca
fluviatilis, Noemacheilus barbatulus, Catostomus commersoni; Esox lucius. Individual
high quality NOEC/(L(E) C10 values from different studies range between
2.2 µg/l Cu for the rainbow troutOncorhynchus mykiss(endpoint
growth) to 188 µg/l Cu for the perchPerca fluviatilis(endpoint
NOECs are used to derive high quality “species geometric mean” NOEC
values for the most sensitive endpoint for each of the 10 species of
fish. These species-specific NOEC/EC10s range from 11.6 µg Cu/L (Oncorhynchus
mykiss,; growth) to 56.2 µg Cu/L (Pimephales notatus, growth). These
values are carried forward to the PNEC derivation.
Important intra-species varibility in NOEC:
L(E) C10 values are observed due to differences in the physico-chemistry
of the test waters. The
effects data from 2 fish species (Pimephales promelas(Erickson et
al., 1996)) andOncorhynchus mykis (Waiwood and Beamish, 1979)
were used to develop a chronic fish Biotic Ligand Model (De
Schamphelaere and Janssen, 2004), useful to the normalization of the
NOECS and thus the reduction of the intra-species variability.
Several papers address the mechanism of
action of copper after acute and/or chronic exposures: Santore et
al.(2001), Handy (2003), Grosell et al.(2002) and Grosell 2007.
Interestingly Grosell et al (2002) provides a mechanistic understanding
of the observed higher sensitivity in smaller organisms.
Within the ecotoxicity data base, a decreased
growth ofO. mykissbelow 7.8 µg Cu/l and above 16 µg Cu/l
indicating an optimal concentration range for copper between 8 & 16 µg
Cu /L. Below 7.8 µg Cu/L, a copper deficiency was observed (Seim et al,
NOECS for Marine fish: 13
high quality chronic single-species NOEC: L(E) C10 values are available
for 2 species of marine fish. Individual
NOEC: L(E) C10 values range between 55 and 123 µg Cu/L (Both values for
Atherinops affinis, reproduction (hatchling growth parameters)). The
retained species-specific NOECs are 55 µg Cu/L for topsmelt Atherinops
affinis and 57.8 µg Cu/L forsheepshead minnow Cyprinodon variegates. The
database contains some records, supportive to the understanding ot f the
mechanism of action on copper. Grosell (2007) provides a mechanistic
understanding of the observed lesset sensitivity in estuarine
environments compared to freshwater or marine environments.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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