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EC number: 215-572-9
CAS number: 1332-65-6
Materials and Methods
The aim of the study was to
examine the effect of copper sulphate (0,1000, 2000, 4000, 8000 or
16,000 ppm) administered to male and female B6C3F1mice in
feed for 13 weeks. The test organisms were observed throughout the
study for signs of clinical toxicity, mortality, bodyweight changes and
food consumption. At the end of the study period all animals were
sacrificed and subject to pathological examinations, sperm morphology
and vaginal cytology. The
study was conducted to a methodology developed by the US National
Toxicology Programme specifically for the test. The study was conducted
in accordance with GLP.
Results and Discussion
There were no mortalities or
signs of clinical toxicity observed in any of the test species during
the duration of the study. Opthalmoscopic examinations revealed no
abnormalities at any dose level tested. At gross pathology, significant
decreases in heart and kidney weight were noted in the high dose males
in the thymus and kidneys of high dose females. There was also a
significant decrease in liver weights in both sexes in the 8000 and
16000 ppm dose groups. Chemical related gross lesions were limited to
the forestomach of 7 male and 4 females in the 16000 ppm dose group. Histopathological
findings included minimal to mild squamous cell hyperplasia with
hyperkeratosis of the forestomach mucosa at the site of the limiting
ridge. Minimal positive staining for copper was present in the liver
and was limited to the high-dose male and female mice. No significant
findings were noted following examination of the sperm morphology and
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