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EC number: 215-572-9
CAS number: 1332-65-6
OECD Guidelines No. 401 (May 1981)Birds were purchased from a commercial source for use in the definitive study. Birds were weighed predose and on day 14 post dose. The doses were administered via gavage with the test substance suspended in Tylose (CMC) with each dose adjusted to the individual body weights of the birds. Food and water were availablead libitumduring the study. Food consumption was not reported. The birds were subjected to 12 hours light and 12 hours dark daily. Temperature and relative humidity were monitored and kept within a narrow range. The birds were observed daily for adverse effects. No mortality was noted during either the range finder or the definitive study. After 14 days the survivors were sacrificed and subjected to macroscopic examination.
The 24 hour and 14 day LC50s are presented in 5.2.1 below. The slopes the 7 and 14 day data are identical and show as a single line on the mortality curve in 4.2.5 above. The slope of the 24 hour curve is 1.36 and the slope of the 14 day curve is 1.30. During post mortem and final autopsies, no anatomical-pathological findings were noted in the thorax or cranial cavities. In the abdomen, there was hyperaemia of the gastrointestinal tract of the acute mortalities.
Additional adverse effects are summarized as follows:
1000 mg/kg – frightened up to 5 days, reduced reflexes through day 7, ruffled feathers, greasy mucosae, soft and greasy faeces, normal food consumption and weight gains, acute symptoms, sedation and incoordination.
1300 mg/kg – apathy til frightened, clearly diminished reflexes, dirty and bristled feathers, greasy mucosae, soft and greasy faeces, reduced food and water consumption and weight gains, acute symptoms, sedation, ruffled, tremor, titubation, abdominal ache, one acute and one delayed mortality.
1600 mg/kg – apathy til frightened, clearly diminished reflexes, dirty and bristled feathers, greasy mucosae, soft and greasy faeces, clearly reduced food and water consumption and weight gains, acute symptoms, sedation, ruffled, tremor, titubation, abdominal ache, seven acute and two delayed mortalities.
1600 mg/kg – all animals died within 24 hours of treatment, acute symptoms, sedation, tremor, titubation, abdominal ache, exohthalmos, and exitus, ten acute mortalities.
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