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EC number: 215-572-9
CAS number: 1332-65-6
Materials and Methods:
Early effects of acute copper exposure in humans consists mainly of
nausea and altered gastric permeability. To assess effects on gastric
response 30 apparently healthy volunteers underwent 2 controlled trials
receiving a solution with (10 mg Cu/l) and without (<0.01 mg Cu/l)
copper sulphate after overnight fasting, in random order.
Ultrasonography was chosen to follow indirectly the gastric emptying
pattern for 120 min. Measurements were expressed as z scores [z =
Results and Discussion:
Results showed that nobody presented symptoms after drinking water
without added copper, while 9 subjects presented nausea after receiving
10 mg Cu/l solution. The group receiving drinking water with 10 mg Cu/l
presented greater antral areas during the first 60 mins of observation.
Individual and mean fitted curves for antral area, calculated and
compared using the linear mixed effects model fit by REML, showed a
group effect of copper on antral area over time (L. Ratio = 23.98,
P<0.0001); the effect was due to delay in decreasing antral area in
copper treated group during the first hour after ingestion. No
differences were found by gender or nausea. Results show a copper effect
on gastric response suggesting that acute exposure to copper in water
modify the first phase of gastric emptying.
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