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EC number: 205-480-7 | CAS number: 141-32-2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in mammalian cells
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract available
Data source
Reference
- Reference Type:
- publication
- Title:
- Genotoxicity of three acrylate compounds in L5178Y mouse lymphoma cells.
- Author:
- Amtower AL, Brock KH, Doerr CL, Dearfield KL, Moore MM
- Year:
- 1 986
- Bibliographic source:
- Envir. Molec. Mutagen. 8 (6): 4
Materials and methods
- Principles of method if other than guideline:
- L5178Y Mouse lymphoma TK Assay
- GLP compliance:
- not specified
- Type of assay:
- mammalian cell gene mutation assay
Test material
- Reference substance name:
- Methyl acrylate
- EC Number:
- 202-500-6
- EC Name:
- Methyl acrylate
- Cas Number:
- 96-33-3
- Molecular formula:
- C4H6O2
- IUPAC Name:
- methyl acrylate
- Details on test material:
- no further data
Constituent 1
Method
- Target gene:
- TK+/-
Species / strain
- Species / strain / cell type:
- mouse lymphoma L5178Y cells
- Metabolic activation:
- without
- Metabolic activation system:
- S-9 (unspecified)
- Test concentrations with justification for top dose:
- 22 µg/mL; other doses not stated
- Details on test system and experimental conditions:
- DURATION
- Exposure duration: 4 h
Results and discussion
Test results
- Species / strain:
- mouse lymphoma L5178Y cells
- Metabolic activation:
- without
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not valid
- Positive controls validity:
- not specified
- Additional information on results:
- Methyl acrylate was mutagenic (~440 mutants/10E+06 survivors) at 22 µg/mL; a dose that gave > 10 % survival.
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
The TS induced primarily small-colony, TFT-resistant mutants which predict that the compound is clastogenic.
Applicant's summary and conclusion
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