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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication, with restrictions.

Data source

Reference
Reference Type:
publication
Title:
Contact dermatitis to butyl acrylate in spectacle frames.
Author:
Hambly EM and Wilkinson DS
Year:
1978
Bibliographic source:
Contact dermatitis 4: 115

Materials and methods

Type of sensitisation studied:
skin
Principles of method if other than guideline:
A 35-year-old woman with eczema on both sides of her nose after wearing spectacles with plastic nasal rests was patch tested with butyl acrylate in 1% olive oil.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid

Method

Route of administration:
dermal
Details on study design:
TYPE OF TEST(S) USED: patch test (epicutaneous test)

ADMINISTRATION
- Vehicle / solvent: 1% Olive oil


Results and discussion

Results of examinations:
Patch test was positive on day 2 and 4 after administration. The patient returned on the 16th day having again worn her spectacles for 10 days. She had developed a widespread eczema. The patch test site to butyl acrylate had flared and was bullous.

Applicant's summary and conclusion