Registration Dossier

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only short abstract in English available (original publication not in english)

Data source

Reference
Reference Type:
publication
Title:
Role of rat liver microsomal fraction in the metabolism of methyl methacrylate to formaldehyde.
Author:
Kotlobskii YB et al.
Year:
1988
Bibliographic source:
Vopr. Med. Khim. 34: 14-17

Materials and methods

Type of study / information:
metabolism
Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid

Results and discussion

Any other information on results incl. tables

The hydrolysis of Butyl acrylate is catalyzed by the carboxylesterase from rat liver microsomes. The kinetic of the formation of butanol is 4 times higher than the methanol formation from methylacrylate and methyl-methacrylate, respectively.

Applicant's summary and conclusion