Registration Dossier
Registration Dossier
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EC number: 205-480-7 | CAS number: 141-32-2
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 Jan 2001 to 30 Jan 2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- Butyl acrylate was tested for relative rates of hydrolysis by porcine hepatic esterase.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Butyl acrylate
- EC Number:
- 205-480-7
- EC Name:
- Butyl acrylate
- Cas Number:
- 141-32-2
- Molecular formula:
- C7H12O2
- IUPAC Name:
- butyl prop-2-enoate
- Test material form:
- other: liquid
Constituent 1
- Radiolabelling:
- no
Administration / exposure
- Duration and frequency of treatment / exposure:
- 2 min, 5 min and 3 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.2, 0.5 and 2 mM
Results and discussion
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parameters
- Toxicokinetic parameters:
- other: n-Butyl acrylate was rapidly hydrolyzed at rates ranging between 54-69 µmoles/min/mg protein (4 - 33 %) after 2 minutes and 43-72 µmoles/min/mg protein (10 - 66 %) after 5 minutes of incubation at 37°C.
Metabolite characterisation studies
- Metabolites identified:
- no
Any other information on results incl. tables
The % conversion results of n-Butyl acrylate (an average of 3 determinations)
Concentration (mM) |
% Conversion / Rate* |
|
At 2 min. |
At 5 min. |
|
2.00 |
4.18 / 69.67 |
10.09 / 67.27 |
0.50 |
18.16 / 75.67 |
43.72 / 72.87 |
0.20 |
32.80 / 54.67 |
65.97 / 43.98 |
* in μmoles / min / mg protein
n-Butyl acrylate was rapidly hydrolyzed at rates ranging between 54-69 µmoles/min/mg protein (4 - 33 %) after 2 minutes and 43-72 µmoles/min/mg protein (10 - 66 %) after 5 minutes of incubation at 37°C.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
