Registration Dossier
Registration Dossier
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EC number: 205-480-7 | CAS number: 141-32-2
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 Jan 2001 to 30 Jan 2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- Butyl acrylate was tested for relative rates of hydrolysis by porcine hepatic esterase.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Butyl acrylate
- EC Number:
- 205-480-7
- EC Name:
- Butyl acrylate
- Cas Number:
- 141-32-2
- Molecular formula:
- C7H12O2
- IUPAC Name:
- butyl prop-2-enoate
- Test material form:
- other: liquid
Constituent 1
- Radiolabelling:
- no
Administration / exposure
- Duration and frequency of treatment / exposure:
- 2 min, 5 min and 3 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.2, 0.5 and 2 mM
Results and discussion
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parameters
- Toxicokinetic parameters:
- other: n-Butyl acrylate was rapidly hydrolyzed at rates ranging between 54-69 µmoles/min/mg protein (4 - 33 %) after 2 minutes and 43-72 µmoles/min/mg protein (10 - 66 %) after 5 minutes of incubation at 37°C.
Metabolite characterisation studies
- Metabolites identified:
- no
Any other information on results incl. tables
The % conversion results of n-Butyl acrylate (an average of 3 determinations)
Concentration (mM) |
% Conversion / Rate* |
|
At 2 min. |
At 5 min. |
|
2.00 |
4.18 / 69.67 |
10.09 / 67.27 |
0.50 |
18.16 / 75.67 |
43.72 / 72.87 |
0.20 |
32.80 / 54.67 |
65.97 / 43.98 |
* in μmoles / min / mg protein
n-Butyl acrylate was rapidly hydrolyzed at rates ranging between 54-69 µmoles/min/mg protein (4 - 33 %) after 2 minutes and 43-72 µmoles/min/mg protein (10 - 66 %) after 5 minutes of incubation at 37°C.
Applicant's summary and conclusion
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