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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication which meets basic scientific principles

Data source

Reference
Reference Type:
publication
Title:
Preliminary project of the standard minimal scope and methods of testing acute toxicity of industrial chemical substances.
Author:
Sokal J et al.
Year:
1980
Bibliographic source:
Pol. J. Pharmacol. Pharm. 32: 223-229

Materials and methods

Principles of method if other than guideline:
6-10 rats were treated with occlusive dermal exposure for 24 h using different doses of test substance (geometrically increasing by progression coefficient 1.5). Animals were observed for 14 days and the LD50 was determined.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Butyl acrylate
EC Number:
205-480-7
EC Name:
Butyl acrylate
Cas Number:
141-32-2
Molecular formula:
C7H12O2
IUPAC Name:
butyl acrylate
Test material form:
other: liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Duration of exposure:
24 h
Doses:
500 - 3840 mg/kg bw
No. of animals per sex per dose:
no data
Control animals:
not specified
Statistics:
LD50 was calculated according to Litchfield and Wilcoxon (1949).

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LDLo
Effect level:
1 700 mg/kg bw
95% CL:
500 - 3 840

Applicant's summary and conclusion

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