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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given: study report which meets basic scientific principles. Original document not available.

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Unnamed
Year:
1971
Reference Type:
review article or handbook
Title:
SIDS Initial Assessment Report for SIAM 15 (n-Butyl acrylate), October 22-25, 2002 Boston.
Author:
OECD SIDS
Year:
2002
Bibliographic source:
UNEP Publications

Materials and methods

Principles of method if other than guideline:
Male albino rabbits were applied with the undiluted test substance under impervious sheeting on the clipped intact skin of the trunk. The animals were immobilized during the 24-hour contact period. Thereafter, excess fluid was removed to prevent ingestion.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
male

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 h
Doses:
no data
No. of animals per sex per dose:
The total number of animals was 12.
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
2 000 mg/kg bw
Clinical signs:
Iritis occurred in the eyes during the 24 hour exposure period with butyl acrylate.
Gross pathology:
Livers were found to be mottled, with prominent acini; kidneys and spleens were congested in victims.

Applicant's summary and conclusion