Registration Dossier
Registration Dossier
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EC number: 205-480-7 | CAS number: 141-32-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Adopted according to OECD SIDS (publicly available peer reviewed source). Original document not available.
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 971
- Reference Type:
- review article or handbook
- Title:
- SIDS Initial Assessment Report for SIAM 15 (n-Butyl acrylate), October 22-25, 2002 Boston.
- Author:
- OECD SIDS
- Year:
- 2 002
- Bibliographic source:
- UNEP Publications
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 0.5 mL of the undiluted test substance were instilled into the eyes of 5 rabbits. The eyes were not rinsed.
- GLP compliance:
- no
Test material
- Reference substance name:
- Butyl acrylate
- EC Number:
- 205-480-7
- EC Name:
- Butyl acrylate
- Cas Number:
- 141-32-2
- Molecular formula:
- C7H12O2
- IUPAC Name:
- butyl prop-2-enoate
- Test material form:
- other: liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL undiluted - Duration of treatment / exposure:
- 24 hour(s)
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- 5
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
Results and discussion
In vivo
Results
- Remarks on result:
- other: no injury on 1, moderate to severe injury on 4 eyes (2 with iritis)
Any other information on results incl. tables
0.5 mL quantities produced no injury on 1, moderate to severe injury on 4 eyes (2 with iritis).
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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