Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Adopted according to OECD SIDS (publicly available peer reviewed source). Original document not available.

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Unnamed
Year:
1971
Reference Type:
review article or handbook
Title:
SIDS Initial Assessment Report for SIAM 15 (n-Butyl acrylate), October 22-25, 2002 Boston.
Author:
OECD SIDS
Year:
2002
Bibliographic source:
UNEP Publications

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
0.5 mL of the undiluted test substance were instilled into the eyes of 5 rabbits. The eyes were not rinsed.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL undiluted
Duration of treatment / exposure:
24 hour(s)
Observation period (in vivo):
no data
Number of animals or in vitro replicates:
5
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no

Results and discussion

In vivo

Results
Remarks on result:
other: no injury on 1, moderate to severe injury on 4 eyes (2 with iritis)

Any other information on results incl. tables

0.5 mL quantities produced no injury on 1, moderate to severe injury on 4 eyes (2 with iritis).

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU