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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Adopted according to OECD SIDS (publicly available peer reviewed source). Original document not available.

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Unnamed
Year:
1971
Reference Type:
review article or handbook
Title:
SIDS Initial Assessment Report for SIAM 15 (n-Butyl acrylate), October 22-25, 2002 Boston.
Author:
OECD SIDS
Year:
2002
Bibliographic source:
UNEP Publications

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
0.5 mL of the undiluted test substance were instilled into the eyes of 5 rabbits. The eyes were not rinsed.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Butyl acrylate
EC Number:
205-480-7
EC Name:
Butyl acrylate
Cas Number:
141-32-2
Molecular formula:
C7H12O2
IUPAC Name:
butyl prop-2-enoate
Test material form:
other: liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL undiluted
Duration of treatment / exposure:
24 hour(s)
Observation period (in vivo):
no data
Number of animals or in vitro replicates:
5
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no

Results and discussion

In vivo

Results
Remarks on result:
other: no injury on 1, moderate to severe injury on 4 eyes (2 with iritis)

Any other information on results incl. tables

0.5 mL quantities produced no injury on 1, moderate to severe injury on 4 eyes (2 with iritis).

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU