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EC number: 205-480-7 | CAS number: 141-32-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given: scientifically acceptable study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
- Principles of method if other than guideline:
- BASF test
- GLP compliance:
- no
Test material
- Reference substance name:
- Butyl acrylate
- EC Number:
- 205-480-7
- EC Name:
- Butyl acrylate
- Cas Number:
- 141-32-2
- Molecular formula:
- C7H12O2
- IUPAC Name:
- butyl prop-2-enoate
- Test material form:
- other: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gaukler, 6050 Offenbach, Germany
- Weight at study initiation: approx. 3.1 kg (mean)
- Sex: male / female
- Diet (ad libitum): Ssniff-K-standard diet/rabbit Intermast, Soest
- Water (ad libitum): tap water
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin sites of the same animals
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): undiluted, no amount specified - Duration of treatment / exposure:
- 1 min, 5 min, 15 min, and 20 h
- Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- Type of wrap if used: patch, no further data
REMOVAL OF TEST SUBSTANCE
- Washing: yes (exposure 1, 5, 15 min) first with undiluted Lutrol 9, then with an aqueous Lutrol solution (50 %); no (exposure 20 h)
- Time after start of exposure: 1, 5, and 15 min, respectively
SCORING SYSTEM:
The original BASF grading was converted into the numerical grading according to the OECD Draize system.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- 15 min exposure
- Basis:
- mean
- Remarks:
- (2 animals)
- Time point:
- other: 24-48-72 h
- Score:
- 3.9
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- edema score
- Remarks:
- 15 min exposure
- Basis:
- mean
- Remarks:
- (2 animals)
- Time point:
- other: 24-48-72 h
- Score:
- 2.9
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- erythema score
- Remarks:
- 20 h exposure
- Basis:
- mean
- Remarks:
- (2 animals)
- Time point:
- other: 24-48-72 h
- Score:
- 3.9
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: 1st Trial
- Irritation parameter:
- edema score
- Remarks:
- 20 h exposure
- Basis:
- mean
- Remarks:
- (2 animals)
- Time point:
- other: 24-48-72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: 1st Trial
- Irritant / corrosive response data:
- Twenty four hours following the 1-, 5- and 15-minute applications strong erythema and edema were seen. The 20-hour exposure (trial 1) caused slight necrosis in addition to erythema and edema. Six and eight days after the applications, slight scaling was observed for the 1-, 5- and 15 -minute applications. The 20-hour application (trial 1) caused parchment like necrosis of the upper skin layer and scaling. The trial 2 of 20 h application resulted into similar responses as observed in trial 1.
Any other information on results incl. tables
Skin Irritation Score, Rabbit 1/2, Erythema
Exposure time |
24 h |
48 h |
72 h |
Mean |
1 min |
4a/3a |
4a/3a |
1/0 |
3/2 |
5 min |
4a/4a |
4a/4a |
2a/4 |
3.3/4 |
15 min |
4a/4a |
4/4a |
3a/4 |
3.7/4 |
20 h (trial 1) |
4a/3a |
4b/4b |
4b/4b |
4/3.7 |
Skin Irritation Score, Rabbit 1/2, Edema
Exposure time |
24 h |
48 h |
72 h |
Mean |
1 min |
3a/3a |
3a/3a |
0/3 |
2/3 |
5 min |
3a/3a |
3/3a |
2a/2 |
2.7/2.7 |
15 min |
3a/3a |
3/3a |
3a/2 |
3/2.7 |
20 h (trial 1) |
3/3 |
3/3 |
3/3 |
3/3 |
a- extending beyond the area of application
b- livid
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