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Categories

Categories

Category name:
Acrylates

Justifications and discussions

Category definition:
The Acrylic Acid and Esters category is defined as a structurally related group of substances including acrylic acid (CAS No. 79-10-7), methyl acrylate (CAS No. 96-33-3), ethyl acrylate (CAS No. 140-88-5), n-butyl acylate (CAS No. 141-32-2), i-butyl acrylate (CAS No. 106-63-8), t-butyl acrylate (CAS No. 1663-39-4), and ethyl hexyl acrylate (CAS No. 103-11-7). All of these chemicals have a common Structure-Activity-Relationship (SAR) to serve as the technical basis for the category.
Category rationale:
Data on physicochemical properties, mammalian toxicity, and environmental and ecotoxicity have been collected for the following substances: acrylic acid (CAS No. 79-10-7), methyl acrylate (CAS No. 96-33-3), ethyl acrylate (CAS No. 140-88-5), n-butyl acylate (CAS No. 141-32-2), i-butyl acrylate (CAS No. 106-63-8), t-butyl acrylate (CAS No. 1663-39-4), and ethyl hexyl acrylate (CAS No. 103-11-7). Because these substances exhibit similarity in their physicochemical properties and toxicological properties in mammals, and because the acrylate esters have been shown to be metabolized in the mammalian body in minutes to acrylic acid and the corresponding alcohol, they can be considered to constitute a chemical category. Data gaps for mammalian toxicity can be addressed by read-across between category members. Because these substances exhibit similarity in their environmental and eco-toxicological properties, data gaps in environmental and eco-toxicity can be addressed by read-across between category members.