Registration Dossier

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.1 mg/m³
Most sensitive endpoint:
sensitisation (respiratory tract)
DNEL related information
DNEL derivation method:
other: The EU indicative OEL for piperazine is used.
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.3 mg/m³
Most sensitive endpoint:
sensitisation (respiratory tract)
DNEL related information
DNEL derivation method:
other: The EU indicative OEL for piperazine is used.

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.3 mg/m³
Most sensitive endpoint:
sensitisation (respiratory tract)
DNEL related information
DNEL derivation method:
other: The EU indicative OEL for piperazine is used.
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.3 mg/m³
Most sensitive endpoint:
sensitisation (respiratory tract)
DNEL related information
DNEL derivation method:
other: The EU indicative OEL for piperazine is used.

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)
Most sensitive endpoint:
skin irritation/corrosion
Acute/short term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)
Most sensitive endpoint:
skin irritation/corrosion
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)
Most sensitive endpoint:
skin irritation/corrosion
Acute/short term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)
Most sensitive endpoint:
skin irritation/corrosion

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
medium hazard (no threshold derived)

Additional information - workers

CHEP is a reaction mass of 2 -piperazine-1 -ylethanol (CAS 103 -76 -4), piperazine-1,4 -diethanol (CAS 122 -96 -3) and piperazine (110 -85 -0). Piperazine is assumed to be the most toxic constituent therefore the data for DNEL derivation is used from piperazine except data is available from reaction mass itself. An EU indicative Occupational Exposure Limit is set. Piperazine is a respiratory sensitiser, and the OEL is set to protect workers from sensitisation although there is no NOAEL determined for this effect. Deriving DNEL's from available NOAEL values gives higher DNEL values. Thus the OEL is used as a DNEL.

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - General Population

There is no intended use of CHEP in consumer products. Therefore, a health hazard due to exposure for the consumer is negligible.