Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Piperazine is neurotoxic to humans. Piperazine is a skin- and respiratory sensitiser to humans.

Additional information

Through its use as an anti-helmintic agent, neurotoxic effects have been noted in humans, both after single dose exposure and repeated doses.

Skin sensitising reactions has been noted among humans exposed to piperazine, and also respiratory sensitisation among workers exposed to piperazine.